Office: Falmouth 3.27 (entrance 2, use lift to floor 3)
Research in the Marakalala lab seeks to identify host factors that drive immunopathogenesis during TB progression. We utilize molecular histology techniques on human lung tissues to characterize different stages of granuloma development. Targeting pathways associated with granuloma collapse and tissue destruction can be exploited for development of host-directed therapies against TB. We are also interested in mycobacterial genes that are conditionally essential for bacterial survival within the host.
Spatial characterization of human TB granulomas
Hyper-inflammation as a target for HDTs against TB
Intra-phagosomal manipulation to potentiate drug efficacy
Targeting Mtb ‘counteractomes’ to potentiate the anti-mycobacterial immunity