Fungai Musaigwa (PhD candidate in the Division of Immunology) and his supervisor ,Dr Justin Nono Komguep, published an article in The Conversation on 12 September 2021 entitled "Worms can affect vaccine efficacy: lessons for COVID-19?". Fungai was then interviewed by Africa Melane on the Early Breakfast show, Cape Talk FM, a few days later. The article and interview focus on how parasitic worms can affect vaccine efficacy.
Division of Immunology and ICGEB researchers Dr Sabelo Hadebe, Dr Jermaine Khumalo, Dr Martyna Scibiorek, Ms Amkele Ngomti, Ms Nontobeko Mthembu, Ms Sandisiwe Mangali, Dr Hlumani Ndlovu, Dr Frank Kirstein and Professor Frank Brombacher, recently authored a paper in JACI. The paper published in December 2020 entitled "Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load". The paper was highlighted in The Editors’ Choice, JACI.
In a recent preprint, Keeton and colleagues aimed to provide an overall measure of immune evasion by assessing neutralizing antibody and T cell responses in 44 South African COVID-19 patients infected either with B.1.351 or infected before its emergence (‘first wave’).
Immunology research update from Immunopaedia.org.za. In an interesting study, researchers showed that neutrophils contribute significantly to IgG-mediated phagocytosis of blood-stage P. falciparum merozoites and protection against febrile malaria. These findings further elucidate neutrophil antibody-mediated immune mechanisms against blood-stage malaria parasites.
Immunology research update from Immunopaedia.org.za. Researchers from the University of Maryland and the US National Institutes of Health have discovered a novel pathway of host cell manipulation and innate immune evasion by Mtb. They have shown that the Mtb limits activation of a host cell defense complex, the inflammasome.
Immunology research update from Immunopaedia.org.za. Researchers aimed to develop a candidate SARS-Cov-2 vaccine that uses the YF17D vaccine as a vector to express a non-cleavable pre-fusion form of the SARS-CoV-2 spike antigen (YF-S0).
Immunology research update from Immunopaedia.org.za. Prof. Lynn Morris began her talk comparing the HIV and SARS-Cov-2 epidemics, at the peak of the HIV epidemic approximately annual mortality was 1.8 million deaths reported due to HIV/AIDS. Fortunately, HIV-associated mortality has drastically decreased due to the successful roll-out of anti-retroviral treatment
Immunology research update from Immunopaedia.org.za. Prof Lynn Morris presented results from the antibody-mediated prevention trial that tested the ability of VRC01 broadly neutralising Ab(specific for the HIV envelope protein CD4 binding site and has a wide coverage of HIV subtype B and C strains. Participants in the AMP trials received 10 doses of VRC01…
Immunology research update from Immunopaedia.org.za. Wang and colleagues aimed to isolate potent neutralising antibodies that have activity against VOCs as well as other SARS-Cov-2 variants, as well as determine whether these potent nAbs have therapeutic potential and can reduce resistance development. Researchers isolated SARS-CoV-2 specific antibodies…
Immunology research update from Immunopaedia.org.za. Researchers are thus investigating different novel vaccination strategies, such as heterologous prime-boost strategies to facilitate mass COVID-19 vaccinations. There are currently multiple trials that are investigating different strategies such as SARS-CoV-2 adenovirus-based vaccine prime- followed by an mRNA vaccine boost and vice versa. In this summary, we report on findings by Borobia et al., 2021 that performed:
Immunology research update from Immunopaedia.org.za. Hepatitis C virus (HCV) is a genetically diverse including six major genotypes and more than 86 subtypes, additionally, HCV has a rapid mutation of HCV leads to viral quasispecies that can escape the immune response in infected individuals. This makes developing HCV vaccines very challenging.
Immunology research update from Immunopaedia.org.za. We highlight Global-ImmunoTalks webinar featuring Dr Tineke Cantaert, Dr Cantaert began her talk highlighting the main focus of her research lab: Investigation of adaptive immune responses to Arboviruses.