Hormonal contraception alters vaginal microbiota and cytokines in SA adolescents
Division of Immunology researchers; Dr Christine Balle (first author), Dr Shameem Z. Jaumdally, Dr Anna-Ursula Happel, Rachel Esra, Enock Havyarimana and Dr Heather Jaspan recently authored a paper in Nature Communications. The paper published in November 2020 is entitled “Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial”.
IL-4Rα signaling in CD4+CD25+FoxP3+ T regulatory cells restrains airway inflammation via limiting local tissue IL-33
Division of Immunology and ICGEB researchers Dr Jermaine Khumalo, Dr Frank Kirstein, Dr Sabelo Hadebe and Professor Frank Brombacher, recently authored a paper in JCI Insight. The paper published in September 2020 is entitled “IL-4Rα signaling in CD4+CD25+FoxP3+ T regulatory cells restrains airway inflammation via limiting local tissue IL-33”
Division of Immunology and ICGEB researchers Dr Tiroyaone M Brombacher, (PhD) Inssaf Berkiks, (PhD) Shandre Pillay, (MSc) Martyna Scibiorek, (MSc) Blessing O. Moses (BSc) and Professor Frank Brombacher (PhD), recently authored a paper in Scientific Reports. The paper published in October 2020 is entitled “IL-4R alpha deficiency influences hippocampal-BDNF signaling pathway to impair reference memory”.
Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in preclinical models
Dr Justin Nono Komguep authored a paper with Professor Frank Brombacher and support from Division of Immunology students and fellows Thabo Mpotje, Dr Nada Abdel Aziz, Dr Lerato Hlaka, Paballo Mosala and Dr Severin Donald Kamdem in Scientific Reports in June 2020. The paper is entitled “Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models”.
Multisystem inflammatory syndrome in children in South Africa
The Cape Town MIS-C team including the Division of Immunology’s Associate Professor William Horsnell and Dr Alisha Chetty contributed to a letter published in Lancet Child Adolescent Health which discusses “Multisystem inflammatory syndrome in children in South Africa” associated with COVID-19.
Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents
PhD candidates Solima Sabeel and Bongani Motaung shared first authors, Dr Mumin Ozturk and Associate Professor Reto Guler of the Division of Immunology in the University of Cape Town published a systematic review protocol in BMJ Open which aims to identify the statin with the greatest ability to reduce systemic inflammation, independent of the underlying disease entity.
Expansion of Host Regulatory T Cells by Secreted Products of the Tapeworm Echinococcus multilocularis
Justin Komguep Nono of the Division of Immunology authored a paper entitled “Expansion of Host Regulatory T Cells by Secreted Products of the Tapeworm Echinococcus multilocularis” published on 8 May 2020 in Frontiers Immunology.
Functional annotation of human long noncoding RNAs via molecular phenotyping
Reto Guler and Frank Brombacher of the Division of Immunology and FANTOM6 project recently co-authored a paper entitled “Functional annotation of human long noncoding RNAs via molecular phenotyping” published on 27 July 2020 in Genome Research.
Immune serum–activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae
William Horsnell of the Division of Immunology recently co-authored a paper entitled “Immune serum–activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae” published on 31 March 2020 in Parasite Immunology.
Preconception helminth infection alters offspring microbiota and immune subsets in mouse model
Donald D. Nyangahu of the Division of Immunology (DOI) recently authored a paper entitled “Preconception helminth infection alters offspring microbiota and immune subsets in mouse model” with co-authors from the DOI; Matthew Darby, Enock Havyarimana, William Horsnell, Heather B. Jaspan published on 31 March 2020 in Parasite Immunology.
Immunology research update from Immunopaedia.org.za. Minhas et al. investigated whether an increase in PGE2 is associated with the development of age-associated maladaptive inflammation and cognitive decline. They focused their research on PGE2 because levels of PGE 2 are increased during neurodegenerative diseases and in monocytes from older (<65 yrs) compared to younger individuals (< 35 yrs).
COVID-19 and SARS-CoV-2 update from Immunopaedia.org.za. Interim analysis indicates that vaccine candidate Ad26.COV2.S is safe and immunogenic in both younger and older adults. This finding, in combination with the results in preclinical challenge studies, has supported our decision to proceed with phase 3 trials to evaluate the efficacy of a single or two-dose regimen of 5×10^10 viral particles of Ad26.COV2.S.
This webinar will be hosted in order to discuss HIV cure research; more specifically, the latest findings on how host immunity plays a role in HIV persistence and perhaps how to exploit what we know to formulate cure strategies. 26th January at 17h00 GMT+2 (South Africa)
COVID-19 and SARS-CoV-2 update from Immunopaedia.org.za. Studies by Hartley et al., & Dan et al., provide hope for long-lasting memory B cell immunity which persists despite a decline in circulating SARS-CoV-2-antibodies. Further, they highlight specific immune compartment that could be used as better markers of persisting immunity.
‘Driving science to promote world health’ with an emphasis on cutting-edge research, training students and staff, mentoring and enhancing research capacity in South Africa.
To use an integrated cohesive immunology programme of research, education and service to combat communicable and non-communicable diseases in South Africa and beyond.
UCT has a strong track record in immunology and aims to become the centre of research in Africa. Most of the research projects are internationally collaborative which is essential for meaningful research.